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Published on: April 27, 2019
Rapidly growing dysembryoplastic neuroepithelial tumor: case report
Oltea Sampetrean1, Taketoshi Maehara, Nobutaka Arai
1Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan. maehara.nsrg@tmd.ac.jp
Neurosurgery
|February 6, 2007
Summary
This case study highlights a rare dysembryoplastic neuroepithelial tumor (DNET) that rapidly grew in a child. Early surgical removal led to complete seizure freedom and no recurrence, suggesting DNETs may not always be stable benign entities.
Area of Science:
- Neuro-oncology
- Pediatric Neurology
- Surgical Pathology
Background:
- Dysembryoplastic neuroepithelial tumors (DNETs) are typically considered slow-growing, benign glioneuronal tumors.
- The evolving understanding of DNETs necessitates case studies that challenge established concepts.
Observation:
- A 9-year-old boy presented with intractable partial seizures and a left temporal lobe lesion.
- Rapid tumor growth was observed within one month, with significant expansion of the enhanced core.
- Pathological examination confirmed a complex form of DNET with distinct glial and glioneuronal components.
Findings:
- The DNET demonstrated aggressive, rapid growth, deviating from its typical benign presentation.
- Surgical resection of the tumor and epileptogenic focus resulted in complete seizure remission.
- The patient remained seizure-free for five years post-surgery without antiepileptic medication.
Implications:
- This case suggests that some DNETs may exhibit rapid growth and not behave as stable benign lesions.
- Early and complete surgical resection is advocated for DNETs presenting with rapid growth or intractable seizures.
- Complete resection may lead to long-term seizure control and improved patient outcomes.