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Related Experiment Videos

Premixed macroporous calcium phosphate cement scaffold.

Hockin H K Xu1, Lisa E Carey, Carl G Simon

  • 1American Dental Association Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, 100 Bureau Drive Stop 8546, Gaithersburg, MD 20899-8546, USA. hockin.xu@nist.gov

Journal of Materials Science. Materials in Medicine
|February 6, 2007
PubMed
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A novel premixed calcium phosphate cement (CPC) scaffold offers a ready-to-use solution for orthopaedic applications. This macroporous material demonstrates excellent biocompatibility and mechanical strength, simplifying surgical procedures.

Area of Science:

  • Biomaterials Science
  • Orthopaedic Engineering
  • Tissue Engineering

Background:

  • Calcium phosphate cement (CPC) is promising for orthopaedics but requires intraoperative mixing, leading to longer surgeries and inconsistent results.
  • Developing a stable, premixed CPC formulation is crucial to overcome these limitations.

Purpose of the Study:

  • To develop a premixed, macroporous CPC scaffold suitable for tissue ingrowth and orthopaedic applications.
  • To evaluate the mechanical properties, porosity, and biocompatibility of the novel scaffold.

Main Methods:

  • A premixed CPC paste was formulated using mannitol as a porogen and fibers, designed to set only upon contact with physiological solution.
  • Flexural strength and porosity were measured for scaffolds prepared with 30% and 40% mannitol.

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  • Osteoblast cell colonization and viability were assessed to determine biocompatibility.

    • Main Results:

    • Premixed CPC scaffolds exhibited significant macroporosity (68.6-74.7%) and flexural strengths of 3.9 MPa (30% mannitol) and 1.8 MPa (40% mannitol).
    • Osteoblast cells successfully colonized the macropores and attached to the hydroxyapatite crystals.
    • Cell viability was comparable to conventional CPC, indicating non-cytotoxicity.

    Conclusions:

    • A premixed, macroporous CPC scaffold was successfully developed using a fast-dissolving porogen and slow-dissolving fibers.
    • The scaffold possesses mechanical strength comparable to bone and sintered hydroxyapatite implants.
    • This innovation offers a biocompatible, non-cytotoxic, and surgically convenient alternative for orthopaedic bone regeneration.