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AI driven 3D subcellular RPE map discovers cell state transitions in establishment of apical-basal polarity

Davide Ortolan1, Pushkar Sathe2, Andrei Volkov1

  • 1Ocular and Stem Cell Translational Research Section, National Eye Institute, NIH, Bethesda, MD USA.

NPJ Artificial Intelligence
|February 9, 2026
PubMed
Summary

Researchers used AI to create a 3D digital twin of retinal pigment epithelium (RPE) cells, revealing how these crucial cells polarize and organize organelles. This discovery offers insights into maintaining RPE function and preventing retinal degeneration.

Keywords:
BiophysicsCell biologyComputational biology and bioinformaticsNeuroscience

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