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Cadherin expression in the developing mouse olfactory system.

Michael R Akins1, Deanna L Benson, Charles A Greer

  • 1Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520-8082, USA.

The Journal of Comparative Neurology
|February 6, 2007
PubMed
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Cadherins (CDHs) are cell adhesion molecules crucial for olfactory system development. This study maps CDH expression in olfactory sensory neurons and glia, revealing their role in forming odor maps and neural circuits within the olfactory bulb.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Odorant receptors guide olfactory sensory neuron (OSN) topography in the olfactory bulb (OB).
  • Cadherins (CDHs), cell adhesion molecules, are vital in the central nervous system but underexplored in the olfactory system.
  • Previous studies showed catenin expression patterns in the developing olfactory system.

Purpose of the Study:

  • To investigate the localization of 11 classical cadherins (CDH1-4, 6, 8, 10-11, 13, 15) in the developing olfactory system.
  • To understand the role of cadherins in olfactory system development, including OSN topography and circuit formation.

Main Methods:

  • Immunohistochemical analysis of cadherin expression in olfactory structures.
  • Spatiotemporal expression profiling of cadherins in neuronal and glial cells.

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Main Results:

  • CDH1, 2, 3, 4, 6, 8, 10, 11, and 13 were expressed in olfactory structures, excluding CDH5 and CDH15.
  • CDH1 and CDH2 localized to OSNs; CDH2 expression in axons correlated with gamma-catenin.
  • CDH3 and CDH11 were found in olfactory ensheathing glia, while CDH2, 4, and 6 were in the neuropil. Projection neurons expressed CDH2, 4, 6, 8, 10, 11, and 13.

Conclusions:

  • Cadherin proteins are strategically positioned in the developing olfactory system.
  • These cadherins likely contribute to the formation of the odorant map and local circuits within the OB.