Related Experiment Video
Updated: Jul 17, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Imaging of iris lesions with high-speed optical coherence tomography
Sophie J Bakri1, Arun D Singh, Careen Y Lowder
1From the Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Background And Objectives:
To image and measure iris tumors with optical coherence tomography (OCT).
Patients And Methods:
High-speed (2,000-4,000 axial-scan/sec and 4-16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy.
Results:
OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion size. Internal reflectivity is correlated with pigmentation. OCT is a convenient non-contact method that provides imaging of the clinically important angle structures (scleral spur and angle recess).
Conclusions:
OCT is a new imaging modality that complements slit-lamp photography and ultrasound biomicroscopy for serial evaluation of iris
Related Concept Videos
01:19Imaging Studies VII: Vascular Imaging
01:27Imaging Studies III: Computed Tomography