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Side-polished multimode fiber biosensor based on surface plasmon resonance with halogen light.

Hong-Yu Lin1, Woo-Hu Tsai, Yu-Chia Tsao

  • 1Chung Cheng Institute of Technology, National Defence University, Taiwan.

Applied Optics
|February 7, 2007
PubMed
Summary

This study introduces a novel surface plasmon resonance (SPR) fiber sensor for precise refractive index (RI) measurements. The developed sensor achieves high resolution, enabling sensitive detection of biomolecules for biochemical sensing and environmental monitoring.

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Area of Science:

  • Photonics and Sensor Technology
  • Biochemical Sensing
  • Nanotechnology

Background:

  • Surface Plasmon Resonance (SPR) is a powerful optical phenomenon used for sensing.
  • Fiber optic sensors offer advantages in remote and in-situ measurements.
  • Developing cost-effective and sensitive biosensors is crucial for various applications.

Purpose of the Study:

  • To propose and demonstrate a novel side-polished multimode fiber SPR sensor.
  • To investigate the sensor's performance for real-time refractive index (RI) detection.
  • To evaluate the sensor's applicability in biochemical sensing and environmental monitoring.

Main Methods:

  • Fabrication of a side-polished multimode fiber coated with a gold thin film.
  • Utilizing a halogen light source and optical spectrum analyzer for SPR curve analysis.

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  • Performing real-time detection experiments with various RI liquids and DNA hybridization.

    • Main Results:

    • Achieved a high resolution of 3 x 10(-6) refractive index units (RIUs) for RI measurements.
    • Demonstrated a significant SPR dip shift of 8.66 nm upon hybridization of target DNA to probe DNA.
    • Exhibited excellent stability, repeatability, and linearity in sensor performance.

    Conclusions:

    • The developed all-fiber multimode SPR sensor is low-cost, disposable, and label-free.
    • The sensor offers high stability, linearity, and potential for real-time detection.
    • The sensor system is suitable for advanced biochemical sensing and environmental monitoring applications.