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Published on: June 3, 2022
Chemistry and biology of resorcylic acid lactones
Nicolas Winssinger1, Sofia Barluenga
1Organic and Bioorganic Chemistry Laboratory, Institut de Science et Ingénierie Supramoléculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000, Strasbourg, France. winssinger@isis-u.strasbg.fr
Abstract:
While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.
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