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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
Published on: August 16, 2011
Genetic manipulation of schistosomes
Paul J Brindley1, Edward J Pearce
1Department of Tropical Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA. paul.brindley@tulane.edu
International Journal for Parasitology
|February 7, 2007
Summary
Gene manipulation in schistosomes faced challenges but is now advancing with new tools. This review covers recent progress in genetic manipulation and transgenesis for these parasitic organisms.
Area of Science:
- Parasitology
- Molecular Biology
- Genetics
Background:
- Schistosomes, parasitic flatworms, have historically presented challenges for genetic manipulation.
- Difficulties include maintaining their life cycle in vitro, lack of cell lines, and large genomes.
Purpose of the Study:
- To review recent advancements in gene manipulation and transgenesis tools for schistosomes.
- To highlight the emerging era of routine genetic manipulation in schistosome research.
Main Methods:
- Review of recent scientific literature on schistosome gene manipulation techniques.
- Analysis of novel approaches for genome and gene expression modification.
Main Results:
- Tangible progress has been made in developing tools for schistosome gene manipulation.
- The field is approaching a stage where genetic manipulation could become routine.
Conclusions:
- Despite previous impediments, significant advancements are paving the way for routine genetic manipulation of schistosomes.
- New tools and approaches are transforming schistosome research capabilities.
