Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Overdose after detoxification: a prospective study.

James D Wines1, Richard Saitz, Nicholas J Horton

  • 1Alcohol and Drug Abuse Research Center (ADARC), McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. jwines@hms.harvard.edu

Drug and Alcohol Dependence
|February 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association between naloxone distribution, buprenorphine treatment and retention and incident high-risk opioid prescribing with opioid overdose death in Kentucky, Massachusetts, New York and Ohio, United States: An exploratory community-level cohort study of data from the HEALing Communities Study.

Addiction (Abingdon, England)·2026
Same author

Gabapentin to achieve HIV viral load suppression in people with risky drinking in Mbarara, Uganda: study protocol for a randomized, double-blinded, placebo-controlled trial (GRAIL).

Trials·2026
Same author

High Prevalence of Unhealthy Alcohol Use Among Persons with HIV, Viral Non-suppression and Any Alcohol Use in Mbarara, Uganda: A Brief Report.

AIDS and behavior·2026
Same author

COVID-19 pandemic-related stress and substance use behaviors among people with HIV - a mixed method analysis.

PloS one·2026
Same author

Cost-effectiveness of community-based interventions for reducing opioid overdose and non-overdose deaths: simulation modeling of HEALing Communities Study.

Lancet regional health. Americas·2026
Same author

Implementation of addiction consult services and bridge clinics in the HEALing communities study in Massachusetts.

Drug and alcohol dependence·2026
Same journal

Impact of medicaid waivers on medication for opioid use disorders in residential facilities: Evidence from twenty-five states.

Drug and alcohol dependence·2026
Same journal

Mental and somatic multimorbidity among individuals with alcohol use disorder: A sex-stratified registry study.

Drug and alcohol dependence·2026
Same journal

Monitoring novel psychoactive substance trends on social media: Analysis of discussions and dashboard implementation.

Drug and alcohol dependence·2026
Same journal

A meta-analysis on the relationship between cultural identity and substance use among indigenous youth.

Drug and alcohol dependence·2026
Same journal

Examining heterogeneity in pathways between alcohol-related factors and drinking during topiramate pharmacotherapy: A person-specific analysis.

Drug and alcohol dependence·2026
Same journal

The impact of severe mental illness on treatment retention and all-cause mortality among people in opioid agonist treatment.

Drug and alcohol dependence·2026
See all related articles

Prior overdose and depressive symptoms predict future non-fatal overdose (OD) in adults after detoxification. Identifying these risk factors can help prevent future OD events, especially among opioid users.

Area of Science:

  • Addiction Medicine
  • Public Health
  • Psychiatry

Background:

  • Non-fatal overdose (OD) is a significant public health concern.
  • Detoxification is a critical juncture for intervention.
  • Predicting future OD risk is essential for prevention efforts.

Purpose of the Study:

  • To identify predictors of non-fatal overdose (OD) in adults post-detoxification.
  • To analyze risk factors for overdose in a cohort of 470 adults.
  • To examine predictors specifically for individuals with problem opioid use.

Main Methods:

  • Multivariable regression analyses were used to examine factors associated with time to OD.
  • Data were collected over a 2-year follow-up period after discharge from an urban detoxification unit.

Related Experiment Videos

  • Separate analyses were conducted for the total sample and a subgroup with problem opioid use.

    • Main Results:

    • Lifetime OD prevalence was 30.9% overall and 42.3% in the opioid problem subgroup.
    • During 2-year follow-up, OD occurred in 16.9% of the total sample and 26.7% of the opioid subgroup.
    • Predictors of increased OD hazard included white race, depressive symptoms, and prior OD; suicidal ideation/attempt was not associated with future OD.

    Conclusions:

    • Non-fatal OD is highly prevalent among detoxification patients, particularly opioid users.
    • Prior overdose is a potent predictor of future overdose events.
    • Depressive symptoms, a modifiable factor, may be a target for overdose prevention interventions.