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Related Experiment Video

Updated: Jul 17, 2026

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion
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Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

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Visualizing the Regenerated Peripheral Nerve In vivo and In vitro.

Chen Jing1, Peng Chenglin, Ren Yong

  • 1College of Bioengineering, Chongqing University, Chongqing, China.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 7, 2007
PubMed
Summary

New methods visualize regenerated peripheral nerve microstructure and nerve growth factor (NGF) mRNA in Schwann cells. This aids understanding of nerve regeneration and gene activity following injury.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Peripheral nerve injury impacts function recovery, necessitating understanding of regeneration.
  • Histological and molecular insights are crucial for studying peripheral nerve regeneration.

Purpose of the Study:

  • To present novel methods for visualizing regenerated peripheral nerve microstructure in vivo.
  • To visualize the subcellular distribution of nerve growth factor (NGF) mRNA in living Schwann cells in vitro.

Main Methods:

  • Development of advanced imaging techniques for three-dimensional (3D) visualization of nerve fiber microstructure and ultrastructure.
  • Application of in vitro methods to track the spatial distribution of NGF mRNA within Schwann cells.

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Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
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Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
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Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

Related Experiment Videos

Last Updated: Jul 17, 2026

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion
06:17

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

Published on: September 1, 2018

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
09:17

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

Main Results:

  • Successful visualization of the 3D microstructure and ultrastructure of regenerated peripheral nerve fibers.
  • Demonstrated visualization of subcellular mRNA distribution for NGF in Schwann cells.

Conclusions:

  • The developed methods offer valuable tools for investigating peripheral nerve regeneration.
  • These techniques facilitate the study of morphological characteristics and spatio-temporal gene activity during nerve repair.