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Updated: Jul 17, 2026
12:29
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Evaluation of hemodynamic perfusion MR images
Onur Agus1, Mehmed Ozkan, Kubilay Aydin
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey. onur.agus@boun.edu.tr
Summary
This study developed a platform for cerebral MR perfusion imaging, calculating relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), and mean transit time (MTT). The system aids in diagnosing and monitoring neurological conditions like subarachnoid bleeding.
Area of Science:
- Medical Imaging
- Neuroscience
- Radiology
Background:
- Hemodynamic perfusion magnetic resonance (MR) imaging is crucial for diagnosing and monitoring neurological disorders, including tumors and stroke.
- Accurate quantification of perfusion parameters is essential for effective clinical application.
Purpose of the Study:
- To develop and evaluate a platform for investigating the theoretical basis of MR perfusion imaging.
- To quantify and compare the diagnostic capabilities of relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), and mean transit time (MTT) in cerebral perfusion studies.
Main Methods:
- A platform was developed for dynamic contrast-enhanced MR imaging to measure perfusion parameters.
- Calculated and quantized rCBV, rCBF, and MTT, displaying them as color images.
- Compared diagnostic capabilities of rCBV, rCBF, and MTT against Digital Subtraction Angiography (DSA) in 16 patients with subarachnoid bleeding and intracranial aneurysms.
Main Results:
- The developed system successfully calculated and displayed key perfusion parameters (rCBV, rCBF, MTT).
- Comparative analysis addressed critical issues in MR perfusion studies, including image registration and region of interest selection.
- The system demonstrated utility in evaluating patients with subarachnoid bleeding and intracranial aneurysms.
Conclusions:
- The proposed cerebral MR perfusion analysis system is a valuable tool for diagnostic and follow-up studies.
- Radiologists found the system useful for perfusion studies and clinical evaluation.
- The quantitative perfusion parameters derived from MRI aid in the characterization and management of cerebrovascular diseases.
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