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Updated: Jul 17, 2026

Chemical Triphosphorylation of Oligonucleotides
Published on: June 2, 2022
N-phosphorylamino acids and penta-coordinate phosphorous compounds in the chemical process of life
Ru-Gang Zhong1, Li-Jiao Zhao, Yu-Fen Zhao
1College of Life Science & Bioengineering, Beijing University of Technology, Beijing, China. lifesci@bjut.edu.cn.
Abstract:
N-phosphorylamino acids can react to form esters, peptides, phosphoryl ester-exchanged products and phosphoryl group migration products under mild conditions which are very important in researches on the origin of life. It has been proposed that the penta-coordinate phosphorous compounds might be the common intermediates of these reactions, which are the key factor to determine the activities. In this paper, the mechanisms of series reactions involving N-phosphorylaminoacids and penta-coordinate phosphorous compounds are studied with computational chemistry methods.
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