Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perception of brain-computer interface implantation surgery for motor, sensory, and autonomic restoration in spinal cord injury and stroke.

Frontiers in neuroscience·2026
Same author

Enhanced hypoxia resistance distinguishes human pluripotent stem cell-derived islets from primary islets.

American journal of physiology. Cell physiology·2026
Same author

Real-time brain-computer interface control of walking exoskeleton with bilateral sensory feedback.

Brain stimulation·2026
Same author

Respiring cultureware for high-density, scalable, multipurpose cell-based bioproduction.

Research square·2026
Same author

Machine learning enhanced noninvasive transcranial stroke detection using a portable eddy current damping sensor.

iScience·2025
Same author

Robotic Ankle Assessment Post-Stroke: Reliability, Comparison to Therapists, and Benchmark Dataset Development.

Sensors (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jan 19, 2026

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

11.3K

A new multi-site probe array with monolithically integrated parylene flexible cable for neural prostheses.

Changlin Pang1, Jorge Cham, Zoran Nenadic

  • 1Caltech Micromachining Lab, California Institute of Technology, Pasadena, CA 91125 USA (phone: 626-395-2254; fax: 626-584-9104;

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 7, 2007
PubMed
Summary

Researchers developed new neural probes using parylene, a flexible polymer, for advanced neural prostheses. These probes offer improved electrical and mechanical properties for recording brain signals.

More Related Videos

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

15.3K
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

35.4K

Related Experiment Videos

Last Updated: Jan 19, 2026

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

11.3K
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

15.3K
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

35.4K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Neural prostheses require advanced probes for high-fidelity signal recording.
  • Traditional inorganic insulators present limitations in flexibility and biocompatibility.

Purpose of the Study:

  • To introduce a novel multi-site neural probe array utilizing parylene insulation.
  • To enhance neural recording capabilities for high-level cognitive signals.

Main Methods:

  • Fabrication of probe arrays using parylene insulation and an all-dry process.
  • Integration of monolithically fabricated parylene flexible cables.
  • Utilizing double-side-polished (DSP) wafers for probe construction.

Main Results:

  • Parylene insulation provides superior electrical resistivity and mechanical flexibility compared to inorganic materials.
  • The developed probes exhibit enhanced electrical and mechanical performance.
  • Successful demonstration of an all-dry fabrication process.

Conclusions:

  • Parylene-based neural probes offer significant advantages for neural prostheses.
  • The technology enables the creation of high-density 3-D arrays for chronic implantation.
  • This advancement facilitates improved recording of cognitive neural signals.