Microencapsulation of insulin into biodegradable microcapsules by the high voltage field method

To produce and evaluate sustained microcapsules of insulin made by a novel encapsulation process. The insulin was encapsulated into microcapsules of poly(D, L-lactide co-glycolide) (PLGA) by the high voltage field method. The preparation process was cryogenic, non-aqueous, and did not utilize emulsification. When the ratio of insulin/PLGA was 1:9, the median particle size of insulin microcapsules was less than 200μm, the drug loaded was 8.82%, and the efficiency of encapsulation was 83.2%. Drug release continued over 300h. In conclusion, the process was a novel way to produce insulin microcapsules, and the basic characteristics were satisfactory.