Suggested shape for a first generation endovascular untethered microdevice prototype

Area of Science:

• Biomedical Engineering
• Medical Devices
• Fluid Dynamics

Background:

• Untethered microdevices are crucial for targeted drug delivery and minimally invasive procedures within the human bloodstream.
• Optimizing microdevice shape is essential for efficient navigation and control in complex biological environments.
• Previous variational Finite Element (FE) analysis provided a foundation for this shape optimization study.

Purpose of the Study:

• To optimize the shape of an untethered microdevice for effective navigation within the human bloodstream.
• To identify a prototype shape that enhances maneuverability and reduces resistance during transit.
• To leverage magnetic resonance imaging (MRI) capabilities for microdevice guidance.

Main Methods:

• Utilized variational Finite Element (FE) analysis to model fluid dynamics and device interaction.
• Investigated various shape parameters to determine optimal design characteristics.
• Simulated device performance under physiological flow conditions.

Main Results:

• The prolate spheroid shape was identified as the optimal design for the first-generation prototype.
• This shape significantly minimizes hydrodynamic drag force during blood flow.
• The prolate spheroid design maximizes the effective utilization of MRI magnetic gradients for steering.

Conclusions:

• The prolate spheroid is a highly effective shape for untethered microdevices navigating the bloodstream.
• This design facilitates efficient propulsion and precise control using MRI guidance.
• The findings pave the way for advanced micro-robotics in clinical applications.