Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Summary of Guidelines for Identifying and Risk-Stratifying Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Primer for Family Physicians.

Diagnostics (Basel, Switzerland)·2026
Same author

Comparison of four attenuation-compensation methods for backscatter coefficient estimation and characterization of focal liver lesions.

Physics in medicine and biology·2026
Same author

Liver Nodule Anomaly Detection Using Ultra-sound Radiofrequency Signals and Variational Autoencoders.

IEEE transactions on bio-medical engineering·2026
Same author

Geographic and Sex Distribution of LI-RADS Research Globally: A Cross-Sectional Meta-Research Study.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes·2026
Same author

Feasibility of Early Oral Nutritional Supplementation After Liver Transplantation: A Randomized Pilot Study.

Clinical transplantation·2026
Same author

Systematic Review: Imaging-Based Morphological Criteria for Liver Cirrhosis-A Call to Standardise.

Alimentary pharmacology & therapeutics·2026
Same journal

Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

Annals of biomedical engineering·2026
Same journal

A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

Annals of biomedical engineering·2026
Same journal

Multidirectional Optical Bone Densitometry Using a Simulation-Based Machine Learning Model: Experimental Validation with Bone Phantoms.

Annals of biomedical engineering·2026
Same journal

Numerical Study of Human Torso Mechanical Response and Injury Assessment Under Blast Loading with Bulletproof Protection.

Annals of biomedical engineering·2026
Same journal

Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Annals of biomedical engineering·2026
Same journal

Screening and Evaluation of Post-stroke Dysphagia: Insights from Neurology, Artificial Intelligence and Data Science-A Scoping Review.

Annals of biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Aug 15, 2025

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
08:26

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Published on: June 5, 2019

6.5K

Design of a Patient-Specific Respiratory-Motion-Simulating Platform for In Vitro 4D Flow MRI.

Ning Li1,2, Cyril Tous1,2, Ivan P Dimov1,2

  • 1Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Rue Saint-Denis, Montreal, QC, H2X 0A9, Canada.

Annals of Biomedical Engineering
|December 29, 2022
PubMed
Summary
This summary is machine-generated.

A novel in vitro testing method validates four-dimensional (4D) flow MRI using a respiratory motion simulator. This low-cost, reproducible system accurately mimics human liver motion, improving 4D flow MRI accuracy.

Keywords:
4D flow MRIIn vitro and in vivoLiver motionRespiratory-motion-simulating platformSignal-to-noise ratio

More Related Videos

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training
09:57

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Published on: January 18, 2021

4.1K
In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
11:16

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging

Published on: February 25, 2022

3.4K

Related Experiment Videos

Last Updated: Aug 15, 2025

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
08:26

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Published on: June 5, 2019

6.5K
Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training
09:57

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Published on: January 18, 2021

4.1K
In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
11:16

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging

Published on: February 25, 2022

3.4K

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Fluid Dynamics

Background:

  • Four-dimensional (4D) flow MRI is a crucial medical imaging technique.
  • In vitro validation offers advantages over in vivo studies for 4D flow MRI, including controlled flow rates and reduced variability.
  • Minimizing animal testing is a key ethical consideration in medical device validation.

Purpose of the Study:

  • To propose a comprehensive in vitro testing method for validating 4D flow MRI.
  • To develop and present a respiratory motion-simulating platform for accurate in vitro assessment.
  • To evaluate the performance of 4D flow MRI under simulated physiological conditions.

Main Methods:

  • A silicon phantom replicating a pig's hepatic arteries was created.
  • Human liver motion was tracked using an MRI navigator and translated into motion parameters.
  • A custom respiratory motion simulator was programmed using velocity-distance data.
  • The simulator's accuracy was verified against volunteer motion data.

Main Results:

  • The respiratory motion simulator achieved motion accuracy within 1 mm of volunteer data.
  • The simulation platform had negligible impact on MRI signal-to-noise ratio.
  • 4D flow measurement errors ranged from 0.4% (stationary) to 33.1% (7 mm gating window).
  • Vessel resolution decreased with larger gating windows.

Conclusions:

  • The developed low-cost respiratory motion simulator provides a reproducible method for in vitro 4D flow MRI validation.
  • The system accurately replicates physiological motion, enabling precise assessment of 4D flow MRI performance.
  • This method enhances the reliability of 4D flow MRI by minimizing confounding factors and improving accuracy.