Related Experiment Video
Updated: Aug 2, 2026

07:40
Multi-Modal Home Sleep Monitoring in Older Adults
Published on: January 26, 2019
Transient unresponsiveness in the elderly. Report of five cases
1Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.
Archives of Neurology
|January 1, 1992
Summary
Elderly patients experienced unexplained unresponsiveness, suggesting a potential age-related arousal disorder. This condition may be more prevalent than currently recognized in geriatric care.
Area of Science:
- Geriatric Medicine
- Neurology
- Sleep Medicine
Background:
- Unexplained episodes of unresponsiveness in hospitalized elderly patients pose diagnostic challenges.
- Exclusion of metabolic, structural, convulsive, and psychiatric causes is crucial for accurate diagnosis.
Observation:
- Five elderly patients presented with recurrent, self-limited episodes of unresponsiveness.
- These episodes were not attributable to known medical or psychiatric conditions.
Findings:
- The observed cases represented approximately 2% of coma evaluations.
- Shared clinical features suggest a distinct, age-related disorder of arousal.
Implications:
- This condition, potentially more common than previously thought, requires further investigation.
- Recognition of this age-related arousal disorder could improve diagnosis and management in geriatric populations.
Related Concept Videos
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

