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Updated: Jul 17, 2026

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
A Bond Graph Approach to the Modeling of Fluid-Solid Interaction in Cardiovascuular System's Pulsatile Flow
A Zadpoor1, A Arshi, A Nikooyan
1Student Member, IEEE, Department of Biomedical Engineering, Amirkabir University of Technology, Hafez Ave., Tehran 15914, Iran (phone: 98-21-8848414; fax: 98-21-8826064;
Abstract:
A bond graph model of entire cardiovascular system is developed in this paper. Although relying on the concepts of previously developed lumped-parameter models, this new model benefits from some advantages of general system theory which allows the modeler to include as many details as necessary. Specifically, inclusion of pace making mechanism has become much easier. The pace making mechanism is not, however, included in this stage of model development. Modular sources of effor are, instead, predicted in the model to genrate synthetic signals close to what occurs in reality. The model is simulated and results of simulation are compared with widely available data of normal cardiovascular system's pressure-flow performance. It has been shown that they are of a good agreement and the model could successfully simuulate performance of the human cardiovascular system.
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