Related Experiment Video
Updated: Jul 17, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells
Evelyn Ullrich1, Mathieu Bonmort, Grégoire Mignot
1Institut National de la Santé et de la Recherche Médicale U805, Faculté de Médecine Kremlin Bicêtre, Villejuif, France.
Abstract:
A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer.
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