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Fos expression in the brainstem nuclei evoked by nasal air-jet stimulation in rats
Isamu Kunibe1, Satoshi Nonaka, Akihiro Katada
1Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Asahikawa, Japan. kunibe@asahikawa-med-u.sl
Background:
Noxious stimulation of the nasal mucosa may induce protective reflexes in the upper airway in rats. Previously, we have reported that nasal air-jet stimulation increases the activities of the laryngeal muscles in decerebrate cats; however, the neuronal mechanism of this phenomenon still is not clarified.
Methods:
After the application of nasal air-jet stimulation for 2 hours, we investigated the distribution of Fos-positive cells (FPCs) throughout the medulla compared with sham-operated rats using Fos immunoreactivity.
Results:
FPCs in the spinal trigeminal nucleus, the parvocellular reticular nucleus, and the nucleus of the solitary tract were more frequent than the sham-operated rats.
Conclusion:
These results suggest that the afferents induced by air-jet stimulation were conveyed to these FPCs and that some of these cells might participate in the augmentation of laryngeal muscle activities during nasal air-jet stimulation.
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