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Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

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A novel HLA-A2 variant, A*9203, identified by sequence-based typing.

C-C Chu¹, H-L Lee, M Lin

¹Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan.

International Journal of Immunogenetics

|February 8, 2007

Summary

A novel Human Leukocyte Antigen (HLA) allele, HLA-A*9203, was identified in Taiwan. Genetic analysis suggests it arose from a gene conversion event involving HLA-A*11 or HLA-A*03 and HLA-A*0207.

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Multi-Locus Sequencing for Strain Typing of Toxoplasma gondii

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Area of Science:

Immunogenetics
Molecular Anthropology

Background:

Human Leukocyte Antigen (HLA) genes are highly polymorphic.
Understanding HLA allele diversity is crucial for transplantation and disease association studies.

Purpose of the Study:

To characterize a newly identified HLA allele, HLA-A*9203, discovered in the Taiwanese population.
To elucidate the evolutionary mechanism behind the formation of HLA-A*9203.

Main Methods:

Sequence-based typing was employed for HLA allele identification.
Comparative sequence analysis was performed to identify nucleotide and amino acid differences.

Main Results:

HLA-A*9203 was found to be identical to HLA-A*0207 in exon 3.
Five nucleotide substitutions in exon 2 of HLA-A*9203 resulted in three amino acid changes compared to HLA-A*0207.
The observed substitution pattern is shared with HLA-A*11 and HLA-A*03 alleles.

Conclusions:

The genetic makeup of HLA-A*9203 suggests a gene conversion event.
A likely mechanism involves gene conversion from HLA-A*11 or HLA-A*03 into an HLA-A*0207 background.
This finding contributes to the understanding of HLA allele evolution and diversity in East Asian populations.