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Identification of a novel HLA-B allele, HLA-B*40:238, in a Taiwanese individual

H-L Lee1, S-K Lai1,2, P-L Chen3,4

  • 1Department of Medical Research, Mackay Memorial Hospital, New Taipei City, Taiwan.

HLA
|July 18, 2017
PubMed

Keywords:
HLA-B*40:238new allelesequencing-based typing

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...