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Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jul 17, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

Intravitreal bevacizumab for filtering surgery.

Jost B Jonas¹, Ulrich H Spandau, Frank Schlichtenbrede

¹Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls University Heidelberg, Mannheim, Germany. jost.jonas@augen.ma.uni-heidelberg.de

Ophthalmic Research

|February 8, 2007

Summary

Intravitreal bevacizumab combined with filtering surgery effectively reduced intraocular pressure in two patients. This approach shows promise for managing complex glaucoma cases, especially neovascular glaucoma.

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Last Updated: Jul 17, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

Area of Science:

Ophthalmology
Vascular Biology

Background:

Investigates intravitreal bevacizumab as an adjunct to filtering surgery for glaucoma management.
Focuses on cases with elevated intraocular pressure secondary to age-related macular degeneration treatment or retinal vein occlusion.

Observation:

A case series involving two patients undergoing penetrating filtering surgery with intravitreal bevacizumab (1.5 mg).
Patients presented with elevated intraocular pressure due to specific ocular conditions.

Findings:

Both patients achieved reduced intraocular pressure (10 and 14 mm Hg) at 4 and 12 weeks post-surgery.
Functioning filtering blebs were maintained in both cases.

Implications:

Intravitreal bevacizumab may enhance outcomes of antiglaucomatous filtering surgery.
The combination therapy shows particular potential for neovascular glaucoma treatment.