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Published on: September 12, 2019
Fatal genital verrucous carcinoma
Shin-ichi Ansai1, Tetsunori Kimura, Masahiro Hayashi
1Sapporo Institute for Dermatopathology, Sapporo, Japan. ansai@sapporo-dermpath.com
The American Journal of Dermatopathology
|February 8, 2007
Summary
This case highlights a rare, fatal verrucous carcinoma of the vulva. Despite initial misdiagnosis as a benign wart, metastasis occurred, emphasizing the need for vigilance in diagnosing this rare cancer.
Area of Science:
- Gynecologic Oncology
- Dermatopathology
- Pathology
Background:
- Verrucous carcinoma is a rare, low-grade variant of squamous cell carcinoma.
- It typically presents on the lower extremities, oral cavity, and genital region.
- This specific case involves the labia majora, a less common site.
Observation:
- A 65-year-old woman presented with a lesion on the labia majora.
- The lesion was initially misdiagnosed as a verruca (wart) over several years.
- Diagnosis of verrucous carcinoma was only confirmed after lymph node metastasis was identified.
Findings:
- Verrucous carcinoma can exhibit subtle histopathologic features, leading to delayed diagnosis.
- Metastasis is uncommon but possible, even in superficially located tumors.
- This case resulted in a fatal outcome due to metastatic spread.
Implications:
- Clinicians should maintain a high index of suspicion for verrucous carcinoma in persistent genital lesions.
- Accurate histopathologic evaluation is crucial, even with seemingly benign initial findings.
- Early detection and appropriate management are vital for improving prognosis in verrucous carcinoma, despite its generally favorable outlook.
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