Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adaptations to fluctuating selection in Drosophila.

Ville Mustonen1, Michael Lässig

  • 1Institut für Theoretische Physik, Universität zu Köln, Zülpicherstrasse 77, 50937 Köln, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|February 9, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community state shifts driven by total carbon availability over resource complexity in a synthetic microbial community.

ISME communications·2026
Same author

Normative assembly rule reveals fairness in microbial communities.

PLoS biology·2026
Same author

Evolution induced state shifts in a long-term microbial community experiment.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Non-ergodicity in ecology and evolution.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Universal bacterial clade dynamics dominate under predation despite altered phenotypes and mutation targets.

Evolution; international journal of organic evolution·2026
Same author

Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals.

Immunity·2026
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Adaptive evolution is driven by time-dependent selection, occurring rapidly in Drosophila. Genomic analysis reveals selection changes are fast, especially in noncoding DNA, highlighting selection as a key evolutionary force.

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Genomics

Background:

  • Adaptive evolution leads to new phenotypes, traceable through genomic data.
  • Standard population-genetic tests for adaptation have limitations in sensitivity.

Purpose of the Study:

  • To analyze polymorphisms and substitutions in Drosophila using a novel, sensitive inference method.
  • To investigate the dynamics of time-dependent selection and its impact on adaptive evolution.

Main Methods:

  • Analysis of polymorphisms and substitutions in Drosophila.
  • Application of a sensitive inference method for detecting adaptations.
  • Comparison of selection change rates in coding and noncoding DNA.

Main Results:

Related Experiment Videos

  • Evidence of strongly time-dependent selection, with changes occurring near the rate of neutral evolution.
  • Adaptive responses are 10-100 times faster than selection changes, indicating efficient adaptation.
  • Selection change rates are higher in noncoding DNA compared to proteins.

Conclusions:

  • Time-dependent selection is a major driver of genomic change, not just a constraint.
  • The rapid pace of selection changes, particularly in noncoding regions, impacts inference of functional elements.
  • Genomic data provides insights into the dynamic nature of adaptive evolution.