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In vivo and in vitro Studies of Adaptor-clathrin Interaction
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Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs

Linton M Traub1, Gergely L Lukacs

  • 1Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA, and Program in Cell and Lung Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada. traub@pitt.edu

Journal of Cell Science
|February 9, 2007
PubMed
Summary

Clathrin-mediated endocytosis uses diverse sorting signals, including ubiquitin, recognized by clathrin-coat-associated sorting proteins (CLASPs). This ensures specific cargo incorporation into vesicles, separating endocytosis from proteasomal degradation.

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