Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ubiquitous occupational exposures have multiple respiratory and extra-pulmonary effects.

American journal of respiratory and critical care medicine·2026
Same author

Influence of Audio Speech Rate and Source Text Difficulty on Health Information Comprehension and Retention.

Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences·2026
Same author

Parallel Corpus Analysis of Text and Audio Comprehension to Evaluate Readability Formula Effectiveness: Quantitative Analysis.

Journal of medical Internet research·2025
Same author

Letter to the Editor "WOEMA Position Paper and Call-to-Action: California needs more physicians specializing in Occupational and Environmental Medicine (OEM)".

Journal of occupational and environmental medicine·2025
Same author

Impacts of Altering Spirometric Prediction Equations in Occupational Health.

Journal of occupational and environmental medicine·2025
Same author

Respirator Medical Examinations: Current Practices and Future Needs.

Journal of occupational and environmental medicine·2025

Related Experiment Video

Updated: Jul 17, 2026

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
11:07

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

Diacetyl-induced lung disease.

Philip Harber1, Kaochoy Saechao, Catherine Boomus

  • 1Division of Occupational and Environmental Medicine, Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA. pharber@mednet.ucla.edu

Toxicological Reviews
|February 10, 2007
PubMed
Summary

Industrial diacetyl exposure, a buttery flavoring, is linked to severe lung disease called bronchiolitis obliterans. This condition causes small airway fibrosis and obstruction, impacting respiratory health.

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
04:45

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Published on: June 2, 2022

Related Experiment Videos

Last Updated: Jul 17, 2026

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
11:07

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
04:45

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Published on: June 2, 2022

Area of Science:

  • Food Chemistry and Toxicology
  • Occupational Health and Respiratory Medicine

Background:

  • Diacetyl is a diketone flavoring agent widely used for its buttery taste.
  • Industrial exposure to flavoring agents, especially diacetyl, has been linked to severe respiratory conditions.

Purpose of the Study:

  • To investigate the association between diacetyl exposure and respiratory illnesses.
  • To understand the mechanism of respiratory damage caused by diacetyl.

Main Methods:

  • Review of industrial exposure cases, particularly in the microwave popcorn industry.
  • Analysis of respiratory symptoms and spirometry abnormalities in affected workers.

Main Results:

  • Diacetyl exposure is associated with bronchiolitis obliterans, characterized by small airway fibrosis and obstruction.
  • Spirometry abnormalities, including fixed airflow obstruction, and respiratory symptoms are linked to exposure.
  • A direct effect on respiratory epithelium with disorganized fibrotic repair is the likely mechanism.

Conclusions:

  • Diacetyl is strongly implicated as the causative agent in occupational lung disease.
  • While diacetyl is the likely culprit, it may serve as a marker for other un identified causative agents.