Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Halothane induced fulminant hepatic failure.

Muhammad Azhar Qureshi¹, Farrukh Saeed, Tassawar Hussain

¹Department of Surgery, PAF, Hospital, Faisal, Karachi. surgazhar@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|February 10, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does patient's position count during Endoscopic Retrograde Cholangio-pancreatography? Left lateral decubitus versus prone position.

Pakistan journal of medical sciences·2023

Same author

Does early application of needle-knife sphincterotomy (NKS) in patients with difficult biliary cannulation increase the risk of postERCP pancreatitis? A single centre study.

Pakistan journal of medical sciences·2023

Same author

The Clinical Implementation of NEWS, SOFA, and CALL Scores in Predicting the In-Hospital Outcome of Severe or Critical COVID-19 Patients.

The Eurasian journal of medicine·2022

Same author

Haematological Parameters And Outcome In Hospitalized Patients With Covid-19: A Developing Country Experience.

Journal of Ayub Medical College, Abbottabad : JAMC·2021

Same author

Bifunctional iron molybdate as highly effective heterogeneous electro-Fenton catalyst and Li-ion battery anode.

Chemosphere·2021

Same author

Ternary Zn<sub>1-x</sub>Ni<sub>x</sub>Se nanostructures as efficient photocatalysts for detoxification of hazardous Congo red, methyl orange, and chrome yellow dyes in wastewater sources.

Environmental research·2021

A rare case of halothane anesthesia causing severe liver failure in a young male is presented. Despite medical support, the patient succumbed to fulminant hepatic failure, confirmed by postmortem liver biopsy.

Area of Science:

Hepatology
Anesthesiology
Pathology

Background:

Halothane is an inhaled anesthetic agent.
Fulminant hepatic failure (FHF) is a rare but severe complication of anesthesia.
Identifying risk factors and mechanisms of drug-induced liver injury is crucial.

Observation:

A 22-year-old male developed fever, jaundice, and coma two days post-laparotomy under halothane anesthesia.
The patient presented with a severely deranged coagulation profile.
Despite intensive supportive care, his condition rapidly deteriorated.

Findings:

The patient died from halothane-induced fulminant hepatic failure six days after surgery.
Postmortem liver biopsy confirmed massive, predominantly centrilobular hepatic necrosis.

Related Experiment Videos

This case highlights the potential for severe hepatotoxicity from halothane.

Implications:

This case underscores the importance of vigilant monitoring for liver dysfunction in patients exposed to halothane.
Understanding the mechanisms of halothane hepatotoxicity can inform anesthetic choices and patient management.
Further research into predicting and preventing halothane-induced liver injury is warranted.