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Updated: Oct 21, 2025

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

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Published on: March 22, 2022

Haematological Parameters And Outcome In Hospitalized Patients With Covid-19: A Developing Country Experience.

Raheel Iftikhar¹, Sultan Mehmood Kamran², Zill-E-Humayun Mirza²

¹Armed Forces Bone Marrow Transplant Centre, National Institute of Blood and Marrow Transplant, Rawalpindi, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC

|September 6, 2021

Summary

Hematological abnormalities like low lymphocyte and platelet counts, and high white blood cell counts, predict COVID-19 severity and mortality. Monitoring these parameters aids in predicting patient outcomes.

Keywords:

Coronavirus; Haematology Cytokine Release Syndrome; Death

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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Area of Science:

Hematology
Infectious Diseases
Critical Care Medicine

Background:

Coronavirus disease 2019 (COVID-19) is a multisystem disorder.
Hematological abnormalities are frequently observed in COVID-19 patients, impacting disease course and outcomes.

Purpose of the Study:

To investigate the association between hematological parameters and COVID-19 severity.
To identify hematological markers that predict mortality in hospitalized COVID-19 patients.

Main Methods:

Retrospective study of 549 hospitalized COVID-19 patients.
Analysis of hematological, coagulation, and inflammatory markers.
Multivariate logistic regression to identify predictors of mortality.

Main Results:

Severe and critical COVID-19 cases showed lower absolute lymphocyte count (ALC) and platelets, and higher white blood cell (WBC) count, neutrophil lymphocyte ratio (NLR), C-reactive protein (CRP), interleukin-6 (IL-6), and lactate dehydrogenase (LDH).
Predictors of mortality included elevated WBC count, NLR, and ferritin, along with decreased platelet count and elevated CRP.
Overall survival was 83.2%.

Conclusions:

Monitoring hematological, coagulation, and inflammatory markers offers a reliable, convenient, and cost-effective method for predicting COVID-19 disease severity, complications, and prognosis.
These parameters are crucial for risk stratification and guiding clinical management of COVID-19 patients.