Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visualizing the histone code on LSD1.

Matthew J Gamble1, W Lee Kraus

  • 1Department of Molecular Biology and Genetics, 465 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA.

Cell
|February 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose-dependent hormone actions at estrogen receptor enhancers specify distinct molecular and biological outcomes.

Science advances·2026
Same author

Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer Cells.

Molecular cancer research : MCR·2026
Same author

PARP16 is a Druggable Regulator of Ribosome MARylation and Protein Homeostasis in Ovarian Cancer Cells.

bioRxiv : the preprint server for biology·2026
Same author

X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer.

Oncogene·2026
Same author

NAD<sup>+</sup> sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis.

Cell reports·2026
Same author

Comprehensive perturbation of transcription factors in human cardiomyocytes reveals the regulatory architecture of congenital heart disease.

bioRxiv : the preprint server for biology·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Histone lysine methylation inhibits unliganded nuclear receptor activity. Ligand-dependent recruitment of histone lysine demethylases, like lysine-specific demethylase 1 (LSD1), reverses this inhibition for transcriptional activation.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Gene Regulation

Background:

  • Unliganded nuclear receptors can spuriously activate transcription.
  • Histone modifications play a crucial role in regulating gene expression.
  • Understanding these regulatory mechanisms is key to deciphering cellular signaling.

Discussion:

  • Garcia-Bassets et al. demonstrate that histone lysine methylation acts as a brake on spurious transcriptional activation by unliganded nuclear receptors.
  • This epigenetic mark establishes an inhibitory code that prevents unwanted gene expression.
  • The study highlights the dynamic interplay between histone modifications and nuclear receptor function.

Key Insights:

  • Histone lysine methylation is a critical inhibitor of aberrant transcription initiation by nuclear receptors.

Related Experiment Videos

  • Ligand-dependent recruitment of histone lysine demethylases, notably lysine-specific demethylase 1 (LSD1), effectively removes this inhibitory mark.
  • This mechanism allows signal-regulated transcriptional activators to override the epigenetic repression.

    • Outlook:

    • Further research into histone demethylases and their role in nuclear receptor signaling could reveal new therapeutic targets.
    • Investigating the broader implications of this inhibitory histone modification code in various cellular contexts is warranted.
    • This work provides a foundation for understanding how epigenetic states are dynamically regulated during signal transduction.