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Published on: October 1, 2019
Exercise-induced increase in lipid peroxidation in patients with chronic heart failure: relation to exercise
Nurten Sayar1, Sait Terzi, Hale Yaka Yilmaz
1Department of Cardiology, Siyami Ersek Cardiovascular Research and Training Hospital, Istanbul, Turkey. sayarnurten@gmail.com
Background:
Little is known about the relationship between exercise intolerance and lipid peroxidation in chronic heart failure (CHF) patients. This study was designed to investigate the relationship between exercise-induced plasma malondialdehyde (MDA) changes in CHF patients and to determine whether there is any association between plasma MDA levels and exercise capacity assessed by cardiopulmonary exercise testing.
Methods:
Cardiopulmonary exercise testing was applied to 31 CHF patients (16 ischemic, 15 idiopathic) and controls. Rest and peak exercise blood samples were analyzed for MDA.
Results:
Patients with CHF had elevation of plasma MDA levels during exercise compared with controls (p < 0.001 vs. p = 0.588). MDA change remained significant both in ischemic and idiopathic cardiomyopathy groups (p < 0.05 and p < 0.01, respectively). Delta MDA (peak exercise MDA - rest MDA) showed significant inverse correlation with peak oxygen consumption in patients with CHF.
Conclusion:
Lipid peroxidation is increased in patients with CHF during exercise regardless of etiology, and this increase is inversely related to oxygen consumption.
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