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The neurosteroid THDOC differentially affects spatial behavior and anesthesia in Slow and Fast kindling rat strains
K Schwabe1, D C McIntyre, M O Poulter
1Department of Neurosurgery, Medical University, MHH, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. schwabe.kerstin@mh-hannover.de
Behavioural Brain Research
|February 13, 2007
Summary
Neurosteroid THDOC (tetrahydrodeoxycorticosterone) affects rat learning differently based on epilepsy breeding. Slow rats
Area of Science:
- Neuroscience
- Neuropharmacology
- Epilepsy Research
Background:
- Rats selectively bred for
- Fast
- or
- Slow
- kindling epileptogenesis exhibit distinct GABA(A) receptor subunit expression, potentially influencing miniature inhibitory postsynaptic currents (mIPSCs).
Purpose of the Study:
- To investigate the differential effects of the neurosteroid tetrahydrodeoxycorticosterone (THDOC) on anesthetic properties and spatial learning in
- Fast
- and
- Slow
- epilepsy rat models.
Main Methods:
- Administration of THDOC at anesthetic (20 mg/kg) and lower (5 mg/kg) doses to
- Fast
- and
- Slow
- rats.
Main Results:
- Anesthetic effect of THDOC was reduced in
- Fast
- rats compared to
- Slow
- rats.
Conclusions:
- THDOC (5 mg/kg) impaired spatial learning in
- Slow
- rats while marginally improving it in
- Fast
- rats, suggesting strain-specific GABA(A) receptor modulation impacts mnemonic functions.
