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Updated: Jul 17, 2026

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster
Published on: September 11, 2013
Wilms tumor genetics: a new, UnX-pected twist to the story
1Department of Cancer Genetics, Unit 1010, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. vhuff@mdacc.tmc.edu
Abstract:
The study of the genetics of Wilms tumor has led to several highly unexpected and precedent-establishing discoveries. Ironically, however, the identification of "WT genes" has been painfully slow, and gene mutations have been identified in only approximately 25% of tumors. The discovery of an X chromosome gene, WTX, that is mutated somatically in approximately 30% of Wilms tumors is notable both for helping to explain the genetic etiology of a substantial proportion of tumors and also for underscoring the role that X chromosome genes can play in cancer genetics.
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