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Human sleep during chronic morphine intoxication.

D C Kay

    Psychopharmacologia
    |October 31, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Chronic morphine use causes persistent sleep disturbances, including altered sleep stages and increased arousal. However, partial tolerance develops, making the effects less severe than with single doses.

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    Area of Science:

    • Neuroscience
    • Sleep Medicine
    • Pharmacology

    Background:

    • Opioid use disorders significantly impact physiological functions.
    • Sleep disturbances are common in individuals using opioids.
    • Understanding the chronic effects of opioids on sleep is crucial for patient care.

    Purpose of the Study:

    • To investigate the effects of chronic morphine administration on sleep architecture and patterns.
    • To assess the development of tolerance to morphine-induced sleep disturbances.

    Main Methods:

    • Polysomnography (EEG, EMG, EOG) was used to monitor sleep in 6 opiate addicts.
    • Sleep was studied over 11 nights across control, induction, and stable dose phases of chronic morphine administration.
    • Doses ranged from 140-220 mg during induction and 240 mg daily during the stable phase.

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    Main Results:

    • Chronic morphine led to persistent sleep disturbances, including less stable delta sleep, increased nighttime awakenings, and decreased REM sleep.
    • Rapid eye movement sleep (RMES) cycles increased, and delta activity bursts were more frequent.
    • Partial tolerance to morphine's sleep-disrupting effects was observed compared to single-dose studies.

    Conclusions:

    • Chronic morphine administration causes a persistent, albeit reduced, sleep disturbance.
    • Partial tolerance to the sleep effects of morphine develops with sustained use.
    • Increased delta bursts may be a specific EEG marker of chronic opioid intake.