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Related Experiment Videos

Pre- and postcontrast MR studies in tuberous sclerosis.

F J Wippold1, W W Baber, M Gado

  • 1Section of Neuroradiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO.

Journal of Computer Assisted Tomography
|January 1, 1992
PubMed
Summary

Magnetic resonance imaging (MRI) reveals key intracranial findings in tuberous sclerosis. Subependymal lesions frequently enhance with contrast, while peripheral lesions show unique T1 signal changes potentially indicating early calcification.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Tuberous sclerosis is a genetic disorder causing tumors in various organs, including the brain.
  • Intracranial manifestations, such as subependymal and peripheral lesions, are common.
  • Understanding the MR characteristics of these lesions is crucial for diagnosis and management.

Purpose of the Study:

  • To report and emphasize previously understressed MR findings in intracranial tuberous sclerosis.
  • To analyze signal intensity patterns and contrast enhancement of subependymal and peripheral lesions.
  • To correlate MR findings with potential pathological processes.

Main Methods:

  • Retrospective review of MR imaging in eight patients with intracranial tuberous sclerosis.
  • Analysis of lesion location (subependymal, peripheral, supratentorial).

Related Experiment Videos

  • Evaluation of signal intensities on proton density, T1, and T2-weighted images, with and without contrast administration.

    • Main Results:

    • All eight patients had supratentorial peripheral lesions (cortical/subcortical); seven had subependymal lesions.
    • The majority of subependymal lesions enhanced with contrast, challenging the notion that enhancement solely indicates actively growing giant cell astrocytomas.
    • Peripheral lesions were hyperintense on PD/T2-weighted images, with half showing elevated T1 signal intensity, possibly indicating early calcification; none enhanced with contrast.

    Conclusions:

    • Contrast enhancement in subependymal lesions may not always signify actively growing tumors.
    • Elevated T1 signal in peripheral lesions is a notable finding that warrants further investigation for early calcification.
    • Distinct MR characteristics of subependymal and peripheral lesions aid in the comprehensive evaluation of tuberous sclerosis.