Related Experiment Video
Updated: Jul 17, 2026
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
[Predictive factors of intestinal stenosis in Crohn's disease]
Héla Elloumi1, Ahmed Ben Abdelaziz, Souhir Sfar
1Service de-Gastro-entérologie, Hôpital Universitaire Sahloul.
Unlabelled:
The aim of our study was to determine demographic, clinical, biological or endoscopic factors that predict intestinal stenosis in Crohn's disease.
Patients And Methods:
One hundred and twenty one patients were retrospectively analyzed during 10 years. The diagnosis of stenosis were determined by morphologic and endoscopic exams independently of appearance of symptoms. The studied characteristics were age at appearance of symptoms, sex, geographical origin, tobacco addiction, symptoms revealing Crohn's disease, extra-digest and auto-immune signs associate and seat of disease. Biological values studied were: haemoglobin, white cells, platelet, erythrocyte sedimentation rate, C- reactive protein and albumin. Predictive factors were assessed using univariate and multivariate analysis.
Results:
Forty-seven patients (38,8%) had a stenosis. In univariate analysis, predictive factors of stenosis were a young age and ileum site of Crohn's disease. In multivariate analysis, none of these variables was independently associated of appearance of stenosis in Crohn's disease.
Conclusion:
This study didn't identify the presence of predictive factors of intestinal stenosis in Crohn's disease that could allow an early specific therapy.
Related Concept Videos
01:25Inflammatory Bowel Disease III: Crohn's Disease
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...