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Topical corticosteroids in infants: prescribing pattern and prescribing errors in Bahrain
Khalid A J Al Khaja1, Awatif H H Damanhori, Thuraya M Al-Ansari
1Department of Pharmacology and Therapeutics, Arabian Gulf University, P.O. Box 22979, Manama, Kingdom of Bahrain. khlidj@agu.edu.bh
Insights
Topical corticosteroid prescribing in Bahraini infants shows significant errors, including inappropriate potency and missing dosage information. Rational prescribing and updated guidelines are crucial for optimal infant skin care.
Area of Science:
- Dermatology
- Pediatrics
- Pharmacology
Background:
- Topical corticosteroids are frequently prescribed for infants.
- Infants are a vulnerable population requiring careful drug selection and administration.
Purpose of the Study:
- To audit topical corticosteroid prescribing patterns and identify errors in infants within Bahrain's primary care setting.
Main Methods:
- A nationwide audit of prescriptions dispensed to infants from 20 primary care centers over two weeks.
- Analysis of 2282 infant prescriptions, identifying topical corticosteroid use and associated prescribing details.
Main Results:
- 13% of infant prescriptions included topical corticosteroids.
- Significant omissions in dosing frequency (21.6%) and therapy duration (43.6%) were noted.
- Inappropriate use of moderate-to-potent corticosteroids and controversial dilution techniques were observed.
Conclusions:
- Topical corticosteroid therapy in infants in Bahrain is suboptimal, characterized by prescribing errors and suboptimal practices.
- Recommendations include establishing treatment guidelines, implementing pharmacovigilance, and revising the essential drug list.
Objective:
A nationwide, primary care-based prescription audit in infants to determine the prescribing pattern and prescribing errors of topical corticosteroid preparations in Bahrain.
Method:
Prescriptions dispensed for infants were collected for two successive weeks from 20 primary-care health centres.
Results:
Among 2282 out of 102,084 prescriptions (2.2%) dispensed for infants, 296 (13.0%) had corticosteroids for topical application to the skin, eye and ear. Plain corticosteroids comprised 6.7%, whereas corticosteroids with antiinfectives accounted for 6.3% of topical corticosteroid preparations. Based on potency the proportions of corticosteroids prescribed were: mild (6.7%), moderately potent (2.6%) and potent (3.7%). The frequency of dosing and length of therapy were not stated in 21.6% and 43.6% of prescriptions, respectively. Base cream as a dilutional vehicle was prescribed in 11.2% (11/98) and 32.4% (12/37) prescriptions containing hydrocortisone acetate 1% cream and betamethasone valerate 0.1%, respectively. In few instances two corticosteroids were concomitantly prescribed.
Conclusion:
Prescribing moderate-to-potent topical preparations in approximately half of the infants, co-prescription of multiple corticosteroid preparations, omission of important components of prescription, and resorting to the controversial vehicle diluting technique suggest that topical corticosteroid therapy is sub-optimal. In infants, topical corticosteroids should be rationally prescribed. Establishing the treatment guidelines, pharmacovigilance programme and revision of the primary care essential drug list are needed in Bahrain.
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