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Published on: November 21, 2019
Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography
Junghwan Oh1, Marc D Feldman, Jihoon Kim
1Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA. jung.oh@mdanderson.org
Background And Objectives:
A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported.
Study Design/Material And Methods:
Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density.
Results:
Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient.
Conclusions:
Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field.
