Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PET imaging in the photosensitive baboon: case-controlled study.

C Akos Szabó1, Shalini Narayana, Peter V Kochunov

  • 1South Texas Comprehensive Epilepsy Center, University of Texas Health Science Center at San Antonio, Texas 78284-7883, USA. Charles.Szabo@uhs-sa.com

Epilepsia
|February 14, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis.

Brain organoid & systems neuroscience journal·2026
Same author

Symptom Overlap and Neurobiological Similarities Between Posttraumatic Stress Disorder and Tinnitus.

Human brain mapping·2026
Same author

Advancing fair and explainable machine learning for neuroimaging dementia pattern classification in multi-racial and multi-ethnic populations.

Nature communications·2026
Same author

Residential Therapy With Navigated Transcranial Magnetic Stimulation for Combat-Related PTSD: A Randomized Clinical Trial.

JAMA network open·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Photosensitive baboons exhibit distinct cerebral blood flow (CBF) patterns during intermittent light stimulation (ILS) compared to asymptomatic controls. These differences in brain activation and deactivation highlight specific network involvement in photosensitive epilepsy.

Area of Science:

  • Neuroscience
  • Primate Models
  • Epilepsy Research

Background:

  • The baboon (Papio hamadryas spp.) serves as a valuable natural primate model for studying photosensitive generalized epilepsy.
  • Understanding cerebral blood flow (CBF) changes during photic stimulation is crucial for elucidating the mechanisms of this condition.

Purpose of the Study:

  • To compare CBF alterations induced by intermittent light stimulation (ILS) between photosensitive (PS) and asymptomatic (CTL) baboons.
  • To investigate the neural correlates of photosensitivity using a primate model.

Main Methods:

  • Six PS and four CTL baboons underwent sequential blood-flow Positron Emission Tomography (PET) studies using O-labeled water.
  • PET imaging was coregistered with MRI, and quantitative CBF analyses were performed for the occipital and motor cortices during resting and ILS conditions.

Related Experiment Videos

  • ILS was administered at 25 Hz.

    • Main Results:

    • Asymptomatic baboons showed ILS-induced activation in frontal, temporal, occipital, and cerebellar regions.
    • Photosensitive baboons displayed distinct activation patterns, including amygdala and globus pallidum involvement, with a notable absence of occipital lobe activation.
    • Both groups exhibited region-specific deactivations during ILS.

    Conclusions:

    • Significant differences in ILS-induced CBF changes were observed between photosensitive and asymptomatic baboons.
    • These findings suggest the involvement of specific cortical-subcortical networks in the pathophysiology of photosensitivity.
    • The baboon model provides insights into the neural basis of photosensitive epilepsy.