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Related Experiment Videos

Feline herpesvirus.

Rosalind Gaskell1, Susan Dawson, Alan Radford

  • 1Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Leahurst, Chester High Road, Neston, S. Wirral, CH64 7TE, United Kingdom. r.m.gaskell@liverpool.ac.uk

Veterinary Research
|February 14, 2007
PubMed
Summary
This summary is machine-generated.

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Feline herpesvirus (FHV-1) causes upper respiratory and ocular disease in cats. While vaccines help, they don't prevent infection, and recovered cats can become carriers, shedding the virus intermittently.

Area of Science:

  • Veterinary Virology
  • Feline Infectious Diseases

Background:

  • Feline herpesvirus (FHV-1) is a significant alphaherpesvirus in cats, closely related to canine and phocine herpesviruses.
  • It is genetically homogenous with a single serotype, primarily causing acute upper respiratory and ocular disease.
  • Increasing evidence points to FHV-1's role in chronic ocular conditions and skin lesions.

Purpose of the Study:

  • To review the epidemiology and clinical significance of Feline herpesvirus (FHV-1).
  • To discuss the pathogenesis, latency, and reactivation patterns of FHV-1 infections.
  • To evaluate the efficacy of current and emerging vaccine strategies against FHV-1.

Main Methods:

  • Literature review of studies on Feline herpesvirus (FHV-1).
  • Analysis of epidemiological data on FHV-1 prevalence and transmission.

Related Experiment Videos

  • Assessment of vaccine efficacy against FHV-1 disease and infection.

    • Main Results:

    • FHV-1 is a primary cause of acute upper respiratory and ocular disease in cats.
    • Latent infections occur in recovered cats, with reactivation triggered by stress, primarily from the trigeminal ganglion.
    • Conventional vaccines offer partial protection against disease but not infection, with limited impact on viral shedding.

    Conclusions:

    • Feline herpesvirus (FHV-1) remains a critical pathogen in feline medicine, necessitating improved control strategies.
    • Understanding latency and reactivation is key to managing chronic FHV-1 related conditions.
    • While current vaccines provide some benefit, further development, including genetically engineered options, is needed for comprehensive protection against FHV-1.