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08:43
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Pattern of recurrence changes in noninvasive bladder tumors observed during 2 decades
Paramananthan Mariappan1, Gordon Smith, Alastair D G Lamb
1Department of Urology, Western General Hospital, Edinburgh, United Kingdom. param.mariappan@nhs.net
The Journal of Urology
|February 14, 2007
Summary
Bladder tumor recurrence risk in G1Ta and G2Ta tumors remained low after 5 years without recurrence. However, contemporary cohorts show a threefold increase in late recurrence, possibly due to improved detection methods.
Area of Science:
- Urology
- Oncology
- Cancer Research
Background:
- Long-term outcomes for G1Ta and G2Ta bladder tumors are crucial for patient management.
- Previous data indicated a low recurrence risk for these tumor types if no recurrence occurred within the first 5 years.
Purpose of the Study:
- To analyze the long-term outcomes of G1Ta and G2Ta bladder tumors across different time periods.
- To compare recurrence patterns between earlier and more contemporary patient cohorts.
Main Methods:
- A review of prospectively maintained computerized records of bladder cancer patients.
- Analysis of long-term outcomes (up to 25 years) in four distinct patient cohorts.
- Comparison of recurrence rates in patients with G1Ta and G2Ta tumors from 1978-1986 and 1991-1996.
Main Results:
- A total of 325 G1Ta and 190 G2Ta bladder tumors were analyzed.
- The initial 5-year recurrence risk was consistent across all cohorts.
- Patients without recurrence in the first 5 years showed a significantly higher late recurrence risk (10.8%) in the 1990s cohorts compared to earlier cohorts (3.2%).
Conclusions:
- A notable difference in late recurrence patterns was observed in contemporary bladder tumor cases.
- Increased intravesical chemotherapy use does not appear to be the primary driver of this change.
- Enhanced lesion detection and biopsy practices may contribute to the observed increase in late recurrences.
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