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Endotracheal castleman disease: A case report
Truc T Pham1, James H Harrell, James H Harrell
1Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Chest
|February 14, 2007
Summary
Castleman disease, a rare lymphoid hyperplasia, can manifest as an endotracheal obstructive mass, causing severe airway compromise. This case highlights a unique presentation of hyaline-vascular Castleman disease in the trachea.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Castleman disease (CD) is a rare lymphoproliferative disorder with diverse clinical and pathological presentations.
- Extranodal manifestations of CD are uncommon, with pulmonary involvement being particularly rare.
- Obstructive airway lesions due to CD have not been previously documented.
Observation:
- A 50-year-old woman with Marfan syndrome presented with respiratory insufficiency due to a near-complete airway obstruction.
- A localized endotracheal lesion was identified as the cause of the obstruction.
- The patient's condition necessitated urgent intervention due to the severity of airway compromise.
Findings:
- The endotracheal lesion was diagnosed as localized hyaline-vascular Castleman disease.
- Comprehensive diagnostic methods, including histopathology, immunohistochemistry, and molecular analysis, confirmed the diagnosis.
- Laser resection was successfully performed to alleviate the airway obstruction.
Implications:
- This case expands the known spectrum of Castleman disease presentations.
- It underscores the importance of considering Castleman disease in the differential diagnosis of obstructive airway masses, even in extranodal locations.
- Early diagnosis and intervention are crucial for managing airway compromise caused by such rare lesions.
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