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Related Concept Videos

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Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
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Related Experiment Video

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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Technology insight: can autoantibody profiling improve clinical practice?

Veronika Sharp1, Paul J Utz

  • 1Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA. vszanya@stanford.edu

Nature Clinical Practice. Rheumatology
|February 15, 2007
PubMed
Summary

Multiplex antigen microarrays offer rapid autoantibody profiling for autoimmune diseases. This technology aids in diagnosing, predicting prognosis, and selecting therapies, though clinical integration challenges remain.

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Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

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Published on: September 15, 2016

Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
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Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)

Published on: October 7, 2009

Area of Science:

  • Immunology
  • Biotechnology
  • Medical Diagnostics

Background:

  • Autoimmune diseases are characterized by specific autoantibodies, crucial for clinical decisions.
  • Multiplex antigen microarrays enable comprehensive autoantibody profiling from biological fluids.
  • Current clinical methods for autoantibody detection are often limited in scope and throughput.

Purpose of the Study:

  • To review available and emerging antigen microarray technologies.
  • To highlight applications of antibody profiling using microarrays.
  • To discuss challenges hindering clinical adoption of these technologies.

Main Methods:

  • Description of current and developmental antigen microarray platforms.
  • Review of recent studies employing microarrays for autoantibody profiling.
  • Analysis of technical and clinical hurdles for microarray implementation.

Main Results:

  • Antigen microarrays provide high-throughput autoantibody identification.
  • These platforms facilitate discovery of novel antibody and antigen biomarkers.
  • Successful applications in profiling autoantibodies for various autoimmune conditions.

Conclusions:

  • Antigen microarrays are powerful tools for advancing autoimmune disease diagnostics and therapeutics.
  • Further development is needed to overcome challenges for widespread clinical use.
  • These technologies hold significant promise for personalized medicine in autoimmune disorders.