Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

TGF-beta type II receptor deficiency prevents renal injury via decrease in ERK activity in crescentic

C Y Song¹, B C Kim, H K Hong

¹Department of Pathology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.

Kidney International

|February 15, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A study on the production method of thin films for low-energy beta measurement.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025

Same author

[The best preferable sagittal vertical axis for the ankylosis spondylitis with thoracolumbar kyphosis following one-level pedicle subtraction osteotomy under different cervical range of motion].

Zhonghua yi xue za zhi·2025

Same author

[Role of intercellular adhesion molecule-1 in adhesion and migration of mesenchymal stem cells in ankylosing spondylitis and its mechanisms].

Zhonghua yi xue za zhi·2024

Same author

Perioperative outcomes of laparoscopic low anterior resection using ArtiSential<sup>®</sup> versus robotic approach in patients with rectal cancer: a propensity score matching analysis.

Techniques in coloproctology·2024

Same author

Digital coincidence counting with 4πβ(PPC)-γ for the standardization of <sup>60</sup>Co.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2024

Same author

Strong correlation between flux pinning and epitaxial strain in the GdBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-</sub> /La<sub>0.7</sub>Sr<sub>0.3</sub>MnO<sub>3</sub> nanocrystalline heterostructure.

RSC advances·2022

Transforming growth factor-beta type II receptor (TGF-betaIIR) deficiency reduces kidney damage in crescentic glomerulonephritis. This suggests TGF-beta signaling is crucial for disease progression by activating ERK and related genes.

Area of Science:

Nephrology
Immunology
Molecular Biology

Background:

The role of transforming growth factor-beta (TGF-beta) receptor complex in crescentic glomerulonephritis (GN) pathogenesis is unclear.
TGF-beta signaling is implicated in kidney disease progression.

Purpose of the Study:

To investigate if TGF-beta signaling is crucial in crescentic GN development and progression.
To determine if TGF-beta signaling activates extracellular signal-regulated kinase (ERK) and its target genes in GN.

Main Methods:

Induced anti-glomerular basement membrane (GBM) GN in TGF-beta type II receptor (TGF-betaIIR) heterozygous mice and wild-type controls.
Assessed renal function, proteinuria, crescent formation, and interstitial volume.
Measured ERK phosphorylation and expression of PAI-1 and alpha2(I) collagen mRNA.

Related Experiment Videos

Main Results:

TGF-betaIIR deficiency significantly reduced renal damage, proteinuria, and crescent formation.
Reduced glomerular and interstitial fibrosis markers were observed in deficient mice.
Decreased renal cortical phosphorylation of ERK and reduced PAI-1 and alpha2(I) collagen mRNA levels were noted.

Conclusions:

TGF-betaIIR deficiency protects against renal injury in experimental crescentic GN.
TGF-beta signaling promotes crescentic GN progression by activating ERK and downstream gene expression.
Targeting TGF-beta signaling may offer a therapeutic strategy for crescentic GN.