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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Fetal growth restriction: relation to growth and obesity at the age of 9 years

Supratik Chakraborty1, Desaline Veronica Joseph, Michael John Gordon Bankart

  • 1Robert Kilpatrick Clinical Sciences Building, University of Leicester, PO Box: 65, Leicester LE2 7LX, UK.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 16, 2007
PubMed

Insights

Children with intrauterine growth restriction (IUGR) exhibit faster growth but remain smaller by age 9. These IUGR infants do not fully catch up in size compared to normal children.

Area of Science:

  • Pediatric Growth and Development
  • Neonatal Medicine

Background:

  • Intrauterine growth restriction (IUGR) affects fetal development, potentially impacting long-term growth trajectories.
  • Understanding post-natal growth patterns in children born with IUGR is crucial for identifying potential health disparities.

Purpose of the Study:

  • To evaluate and compare the growth patterns of 9-year-old children, specifically examining differences between those with and without a history of intrauterine growth restriction (IUGR).

Main Methods:

  • Longitudinal study tracking 75 children at ages 9 (41 with IUGR history).
  • Measurements included weight and height at birth, 1, 2, and 9 years.
  • General linear models analyzed changes in weight z-scores to quantify growth rates.

Main Results:

  • IUGR children were significantly smaller at birth (weight z-score -2.1 vs. 0.2).
  • IUGR children showed a greater increase in weight z-scores between birth and 9 years (1.5 vs. 0.4).
  • At age 9, IUGR children had lower weight, height, and BMI z-scores compared to controls.

Conclusions:

  • Infants born with IUGR experience accelerated post-natal growth but do not fully compensate for early size deficits by age 9.
  • IUGR, birth weight, and parental heights are significant predictors of growth differences observed at age 9.
Abstract

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