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Three-dimensional relationship between high-order root-mean-square wavefront error, pupil diameter, and aging.

Raymond A Applegate1, William J Donnelly, Jason D Marsack

  • 1Visual Optics Institute, College of Optometry, University of Houston, Texas 77204, USA. rapplegate@uh.edu

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
|February 16, 2007
PubMed
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High-order wavefront error (HO RMS WFE) in the human eye increases with pupil size more than age. At low light, HO RMS WFE decreases with age, providing normative data for eye care professionals.

Area of Science:

  • Ophthalmology
  • Optometry
  • Vision Science

Background:

  • Wavefront error (WFE) impacts visual quality.
  • High-order aberrations (HOAs) are crucial for understanding visual function.
  • Age and pupil size significantly influence ocular aberrations.

Purpose of the Study:

  • To quantify root-mean-square (RMS) wavefront error (WFE) for individual aberrations and cumulative high-order (HO) RMS WFE in the normal human eye.
  • To determine the relationship between HO RMS WFE, age, and pupil diameter.
  • To investigate the influence of luminance on HO RMS WFE at physiologic pupil diameters.

Main Methods:

  • Measured ocular aberrations in 146 healthy individuals aged 20-80 years.
  • Analyzed aberrations using a tenth-radial-order normalized Zernike expansion for pupil diameters from 3 to 7 mm.

Related Experiment Videos

  • Developed a planar function to model the relationship between HO RMS WFE, age, and pupil diameter.

    • Main Results:

    • HO RMS WFE increases more rapidly with pupil diameter than with age alone.
    • A planar function explained 99% of the variance in HO RMS WFE across age and pupil diameter.
    • At low luminance (9 cd/m2), HO RMS WFE decreased with increasing age for physiologic pupil sizes.

    Conclusions:

    • Established a 3-D normative data set for HO RMS WFE as a function of age and pupil diameter.
    • Provided insights into the interplay of age, pupil size, and luminance on ocular aberrations.
    • The findings offer valuable data for understanding age-related changes in visual optics.