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Palatability of angiotensin II antagonists among nephropathic children

Chiara M Meier1, Giacomo D Simonetti, Silvia Ghiglia

  • 1Ospedale San Giovanni Bellinzona and Ospedale della Beata Vergine, Mendrisio, Switzerland.

British Journal of Clinical Pharmacology
|February 17, 2007
PubMed

Insights

Pediatric kidney disease patients found pulverized candesartan cilexetil significantly more palatable than other angiotensin II receptor blockers. This taste preference is crucial for medication adherence in children.

Area of Science:

  • Pharmacology
  • Nephrology
  • Pediatrics

Background:

  • Medication palatability is critical for treatment adherence in pediatric patients.
  • Previous research has assessed the palatability of pediatric antimicrobial suspensions using visual analogue scales.

Purpose of the Study:

  • To compare the taste and smell acceptability of five angiotensin II receptor blockers (ARBs) in children with kidney disease.
  • To determine if ARB palatability influences adherence in pediatric nephrology patients.

Main Methods:

  • Twenty-one pediatric patients with kidney disease participated in the study.
  • The palatability of five ARBs (candesartan cilexetil, irbesartan, losartan, telmisartan, valsartan) was assessed using a visual analogue scale.
  • Tablets were pulverized to enhance palatability assessment.

Main Results:

  • Candesartan cilexetil received significantly higher palatability scores compared to irbesartan, losartan, telmisartan, and valsartan.
  • The taste of pulverized candesartan cilexetil was rated superior by the pediatric participants.

Conclusions:

  • This study is the first to compare ARB palatability in pediatric kidney disease patients.
  • Pulverized candesartan cilexetil demonstrates superior taste acceptability among children with kidney disease compared to other evaluated ARBs.
  • Improved palatability of candesartan cilexetil may enhance medication adherence in this population.
Abstract

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