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Published on: October 13, 2023
[Studies on secretion function of normal and transferred submandibular glands]
Guang-yan Yu1, Li-ling Wu, Yan Zhang
1Peking University School and Hospital of Stomatology, Beijing 100081. gyyu@263.net
Summary
Researchers explored submandibular gland (SMG) secretion, finding alpha- and beta-adrenoceptors regulate saliva. Phenylephrine successfully stimulated transferred SMG secretion, offering insights for gland function regulation.
Area of Science:
- Salivary Gland Physiology
- Adrenergic Receptor Signaling
- Glandular Transplantation
Background:
- Understanding submandibular gland (SMG) secretion mechanisms is crucial for treating salivary dysfunction.
- Investigating methods to artificially regulate the function of transferred SMG is essential for reconstructive surgery.
Purpose of the Study:
- To elucidate the secretion mechanisms of normal and denervated submandibular glands.
- To explore artificial regulation of secretion in transferred submandibular glands.
Main Methods:
- Investigated adrenoceptor (AR) expression (alpha(1A), alpha(1B), beta(1), beta(2)) in human and rabbit SMG.
- Examined the role of Vanilloid Receptor 1 (VR1) and capsaicin in rabbit SMG secretion.
- Utilized a rabbit model of microvascular SMG transfer, infusing phenylephrine via Wharton's duct.
Main Results:
- Functional alpha- and beta-ARs were identified in human and rabbit SMG, regulating saliva and alpha-amylase secretion.
- VR1 activation by capsaicin significantly increased rabbit SMG secretion.
- Phenylephrine infusion in transferred rabbit SMG significantly enhanced secretion without adverse cardiovascular effects.
Conclusions:
- Alpha- and beta-adrenoceptors play key roles in regulating SMG secretion.
- Phenylephrine effectively stimulates transferred SMG secretion, potentially via alpha1-AR upregulation and AQP5 translocation.
- Findings provide a basis for understanding and regulating normal and transferred SMG function.
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