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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

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Related Experiment Video

Updated: Jul 16, 2026

Isolation of Epithelial Cells from Human Dental Follicle
04:07

Isolation of Epithelial Cells from Human Dental Follicle

Published on: November 5, 2021

[Research advances in tooth agenesis].

Hai-lan Feng1, Xiao-xia Zhang, Hua Wu

  • 1Department of Prosthodontic, Peking University School & Hospital of Stomatology, Beijing 100081, China. bqfenghl@bjmu.edu.cn

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|February 17, 2007
PubMed
Summary

Oligodontia, the congenital absence of six or more teeth, involves complex genetic factors. Research identifies specific gene mutations in syndromic cases like Rieger Syndrome and ectodermal dysplasia, while non-syndromic forms show greater genetic heterogeneity.

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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

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Last Updated: Jul 16, 2026

Isolation of Epithelial Cells from Human Dental Follicle
04:07

Isolation of Epithelial Cells from Human Dental Follicle

Published on: November 5, 2021

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Area of Science:

  • Dental Anomalies
  • Human Genetics
  • Developmental Biology

Context:

  • Tooth agenesis is a common human developmental anomaly.
  • Oligodontia is defined as the congenital absence of six or more teeth.
  • Understanding the genetic basis of oligodontia is crucial for diagnosis and treatment.

Purpose:

  • To review current research progress in clinical phenotypes, epidemiology, and genetic studies of oligodontia.
  • To summarize molecular genetic findings from collected oligodontia cases.
  • To classify oligodontia into syndromic and non-syndromic forms.

Summary:

  • Syndromic oligodontia cases revealed mutations in PITX2 (Rieger Syndrome) and ED1 (X-linked hypohidrotic ectodermal dysplasia).
  • Non-syndromic oligodontia exhibits significant genetic heterogeneity, with PAX9 and MSX1 identified as associated genes.
  • Cleidocranial dysplasia families showed CBFA1 gene mutations, linked to tooth eruption abnormalities and accessory teeth.

Impact:

  • Identifies specific gene mutations responsible for syndromic oligodontia, aiding in targeted diagnostics.
  • Highlights the genetic complexity of non-syndromic oligodontia, paving the way for further etiological research.
  • Provides a comprehensive overview of oligodontia genetics, valuable for researchers and clinicians in dentistry and genetics.