Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps
Lijie Zhai1, Yiqing Sun, Linghao Tang
1Department of Otolaryngology, First Affiliated Hospital of Dalian Medical University, Dalian. China.
Objectives:
We explored a potential association between nasal polyps (NPs) and polymorphism at loci for human leukocyte antigen (HLA) DR and HLA-DQ.
Methods:
Polymorphism at loci HLA-DR and HLA-DQ were examined in 30 patients with NPs and in 81 healthy subjects by use of the polymerase chain reaction-sequence specific primer method.
Results:
HLA-DR16, HLA-DQ8, and HLA-DQ9 were found to be significantly associated with NPs. HLA-DR16, HLA-DQ8, and HLA-DQ9 specificities were found at higher frequencies in patients with NPs than in control subjects (5% versus 0.62%, RR = 8.9, p = .03; 10% versus 2.47%, RR = 4.81, p = .01; and 20% versus 6.18%, RR = 4.73%, p = .001; respectively). In contrast, HLA-DQ7 was found at lower frequencies in patients with NPs than in controls (10% versus 20.37%, RR = 0.36, p = .04).
Conclusions:
We conclude that HLA-DR16, HLA-DQ8, and HLA-DQ9 represent potential susceptibility determinants and that HLA-DQ7 might confer resistance in nasal polyps.
